Marios C. Yiannakas1,
Ahmed T. Toosy1, Rhian E. Raftopoulos1, Raj Kapoor1,
David H. Miller1, Claudia Angela M. Wheeler-Kingshott1
1NMR
Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL
Institute of Neurology, London, WC1N 3BG, United Kingdom
A new image acquisition and analysis protocol is presented here for fast and reliable segmentation of the intraorbital optic nerve which employs an improved image acquisition scheme in conjunction with a robust image analysis method commonly used for the segmentation of the cervical cord, a similar model to the intraorbital optic nerve. The images obtainable with the use of the proposed acquisition protocol allow highly reproducible measurements of the mean cross-sectional area of the intraorbital optic nerve.