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Abstract #1197

Cortical Thinning in Young Psychosis and Bipolar Patients Correlate with Common Neurocognitive Deficits

Sean Nicholas Hatton1, Jim Lagopoulos1, Daniel F. Hermens1, Elizabeth Nicholas Scott1, Ian B. Hickie1, Maxwell R. Bennett1

1Clinical Research Unit, Brain & Mind Research Institute, Camperdown, NSW, Australia

We investigated cortical changes in young people with psychosis or bipolar disorder and the relationship between cortical thinning and neurocognitive performance. Although the groups exhibited some differences in regional cortical thinning, the shared regions of cortical thinning were correlated with neurocognitive deficits in visual sustained attention, semantic verbal fluency, and verbal learning and memory that are commonly reported in young people with either psychosis or bipolar disorder. While these disorders may have differing neuropathological origins, it is these shared regions of cortical thinning that most significantly impact the lives of young people with psychosis or bipolar disorder.

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Keywords

abnormalities academy active adjacent adjusted administration angular assess assessed assessment associating association attention audience auditory automated battery bipolar brain children clinical cognitive cohorts commentary common compendium comprehension comprising computerized consistent continuously contrast controlled controls controversial conversely correlate correlated cortical course decisions deficits derived developmental diagnosis dimensional disorder disorders domains dosage earlier educational episode episodic established evident exhibit exhibited extensive extra features flexibility fluency frontal fusiform global illness indicative inferior intra investigated language learning life literature lives lobe longitudinal making maps maxwell measured medication memory mental mind mood namely nature oral origins oxford paired paper parietal pathological patient patients patterns people performance phonological predominantly predominately press previously proceedings process processing proper psychiatric psychiatrists psychiatry psychosis rapid regional relationships reports require researchers residual risk sample sciences scores semantic several severe significantly strongly structure studies subjects superior sustained target task temporal thinning unclear underwent unit ventral verbal visual whether word worse years young younger