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Abstract #1188

GABA and Glutamate Abnormalities in the Superior Temporal Gyrus and Their Association with Electrophysiological Abnormalities in Schizotypal Personality Disorder and Schizophrenia

Alexander Peter Lin1, Sai K. Merugumala1, Huijun Liao1, Margaret Niznikiewicz2, Kevin Spencer3, Yoji Hirano3, Robert McCarley3

1Center for Clinical Spectroscopy, Department of Radiology, Brigham and Women's Hospital, Boston, MA, United States; 2Laboratory of Neuroscience , Veterans Affairs Boston Healthcare System, Brockton, MA, United States; 3Laboratory of Neuroscience, Veterans Affairs Boston Healthcare System, Brockton, MA, United States

Many studies have shown that the superior temporal gyrus (STG) undergoes volumetric reductions in schizotypal personality disorder (SPD) and in schizophrenia (SZ) that are associated with electrophysiological abnormalities however to our knowledge, this region of the brain has not been examined with magnetic resonance spectroscopy (MRS), specifically focusing on neurotransmitters glutamate (Glu) and gamma-amino-butyric-acid (GABA). We here report SZ and SPD subjects have reductions of left STG GABA concentrations there are inversely correlated with gamma band oscillations (GBO) and Glu increases that are directly correlated with GBO (higher Glu, worse GBO PLF).

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