Meeting Banner
Abstract #1185

Real-Time fMRI Neurofeedback Training of Amygdala Alters Resting-State Default Mode Network Connectivity in Major Depressive Disorder

Han Yuan1, Raquel Phillips1, Kymberly D. Young1, Vadim Zotev1, Masaya Misaki1, Jerzy Bodurka1, 2

1Laureate Institute for Brain Research, Tulsa, OK, United States; 2College of Engineering, University of Oklahoma, Norman, OK, United States

We investigated possibility of brain plasticity effects in depressed subjects subjected to the real-time fMRI neurofeedback (rtfMRI-nf) training of amygdala activity during happy autobiographic memory recall. We compared the resting-state default-mode network (DMN) functional connectivity before and after rtfMRI-nf. Significant difference of DMN connectivity was found in the subjects after neurofeedback: increased in the medial prefrontal cortex and the posterior cingulate cortex, but decreased in the right medial temporal gyrus. The within-group, correlation analysis found positive correlation between the difference of DMN connectivity and the happiness/memory scores during the neurofeedback. Our results demonstrate sustainable changes within DMN induced by rtfMRI-nf.

Abstract PDF

Keywords

abnormal activation active activity alters analyzed anxiety approaches assigned audience autobiographical best bilateral body brain characteristics choosing clinical component components conducted connectivity corrected correction correlated correlation correspond cortex courses cross custom days decrease decreased default define demographic depression depressive development discovery disorder disorders electric elements emotion engineering evaluated evoking expressed eyes five functional happiness happy identified induced instructed intensity laureate looked major maps memories memory middle mode mood motion network noise normalization novel patients pattern pharmacological pilot plasticity pneumatic positive positively posterior potential preprocessed profile promise proportional protocol psychiatric psychiatry questionnaire random randomly rating real recall recalled receiving recoding regulation removal reported respective respectively respiration respond rested resting sample scale scanner scanning score scores screen seeking selected sense separate separated session sessions severity sham smoothing software space spatial strength subject subjects successful suggested superior system table target targeted targeting temporal therapeutic training trait treatments utilizing visit volumes waveform whole young yuan