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Abstract #1162

Functional Connectivity in Posterior Cingulate Cortex Alters in Brain Concussion Patients at the Acute Stage

Armin Iraji1, Valerie Mika2, Jie Yang2, Annalise Rahman2, Grace Ma2, Robert Welch2, Randall Benson2, Scott Millis2, Hamid Soltanian-Zadeh3, Ewart Mark Haacke2, Zhifeng Kou2

1Biomedical Engineering, Wayne State University, Detroit , MI, United States; 2Wayne State University, Detroit, MI, United States; 3University of Tehran, Tehran, Iran

mTBI affects over 1 million emergency visits in the United States each year. Most of them have negative findings in clinical imaging in emergency department. However, attention and memory deficits are wide-spread symptoms in mTBI patients. We hypothesize that mTBI is associated with alterations in the activities in PCC and functional connectivity at rest. Results demonstrate that a) mTBI patients have alterations in their resting-state functional connectivity in PCC and related areas at the acute stage, and b) this functional connectivity change may reflect their memory symptoms. This work could have potential applications in clinical diagnosis of mTBI.

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Keywords

acquisition activation active activities activity acute acutely addition affine alterations alters among applications applied assessment atlas attention averaging back biomedical brain clinical cluster cognitive common components concussion confirming connectivity controls converted corrected correction correlation cortex cross decrease decreases delayed detecting discriminate distribution dual emergency engineering especially exist extracted eyes females filter filtering finding findings fisher fluctuation frequency front functional gift global gradient healthy hours hypothesize immediate individual individuals injury instructed intensity interactions investigate keep largest local maintain males materials measuring memory mild million mode motion neural normalization often orientation parts pass patient patients posterior potential previous projection proposed recall reflect registered registering regressing regression related resolution respectively rest resting reveals room sample seed selection significantly simulation since slice software space spatial spontaneous stage statistical statistically status step steps studies subjects surrounding symptoms system table template temporal theory threshold timing transformation traumatic unable unlike variance visits volumes white whole yang year years