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Abstract #1139

Application of MOBILE (Mapping of Oxygen by Imaging Lipids Relaxation Enhancement) in Stroke : Preclinical and Clinical Studies.

Florence Colliez1, Caroline Vandeputte2, Uwe Himmelreich3, Thierry Duprez4, Benedicte Jordan5, Bernard Gallez1, Julie Magat6

1Louvain Drug Research Institute, Biomedical Magnetic Resonance Research Group, University of Louvain, Brussels, Belgium; 2Biomedical Nuclear Magnetic Resonance Unit,, KUL, Leuven, Belgium; 3Biomedical Nuclear Magnetic Resonance Unit,, KU Leuven, Leuven, Belgium; 4Radiology and Medical Imaging, St. Luc hospital, Institute of Neuroscience, UCL, Brussels, Belgium; 5Louvain Drug Research Institute, Biomedical Magnetic Resonance Research Group, UCL, Brussels, Belgium; 6Louvain Drug Research Institute, Biomedical Magnetic Resonance Research Group, UCL , Brussels , Belgium

There is a critical need for methods able to monitor dynamically and noninvasively brain oxygenation in clinical practice. Variations in T1 and T2* are potentially valuable magnetic resonance imaging (MRI) tools to quantify changes in tissue oxygenation. T1 is sensitive to dissolved oxygen which acts as a T1-shortening paramagnetic contrast agent. However, this technique lacks of sensitivity. The aim of the current work was to apply the MOBILE technique (for Mapping of Oxygen By Imaging Lipids relaxation Enhancement) to map variations in oxygenation based on the changes in the relaxation properties of the tissue lipids, by exploiting the higher solubility of oxygen in lipids than in water on a photothrombic stroke model and clinical strokes.

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Keywords

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