Meritxell Garcia1,
2, Thomas W. Okell3, Monika Gloor4, Michael A.
Chappell5, 6, Peter Jezzard3, Oliver Bieri4,
James V. Byrne2
1Division
of Diagnostic & Interventional Neuroradiology, Department of Radiology,
Clinic of Radiology & Nuclear Medicine, University of Basel Hospital,
Basel, Switzerland; 2Nuffield Department of Surgical Sciences and
Department of Neuroradiology, University of Oxford, Oxford, United Kingdom; 3Centre
for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, Oxford, United Kingdom; 4Division
of Radiological Physics, Department of Medical Radiology, University of Basel
Hospital, Basel, Switzerland; 5Institute of Biomedical
Engineering, Department of Engineering, University of Oxford, Oxford, United
Kingdom; 6Centre for Functional Magnetic Resonance Imaging of the
Brain, University of Oxford, Oxford, United Kingdom
The role of Flat Panel Detector-CT (FPD-CT), a novel and fast technique able to provide parenchymal blood volume data, was analysed in arteriovenous malformations (AVMs). FPD-CT perfusion was compared to Dynamic Susceptibility Contrast MRI (DSC-MRI) and Arterial Spin Labelling (ASL). Contrary to previous ischaemia studies, FPD-CT values correlated better with CBF than with CBV. This can be explained by the early appearance of contrast agent in the superior sagittal sinus, generally used as the trigger time point for data acquisition, due to the high-flow shunting effect in AVMs. This challenges the utility of FPD-CT for reliable perfusion analysis in AVMs.