Meeting Banner
Abstract #1096

Optimization of GSH Measurement in Multiple Sclerosis

Huijun Liao1, Sai K. Merugumala2, Shahamat Tauhid3, Rohit Bakshi3, Alexander Lin2

1Center for Clinical Spectroscopy , Brigham and Women's Hospital, Boston, MA, United States; 2Center for Clinical Spectroscopy, Brigham and Women's Hospital, Boston, MA, United States; 3Laboratory for Neuroimaging Research, Department of Neurology, Brigham and Women's Hospital, Boston, MA, United States

Glutathione (GSH) is as a marker for oxidative stress that may be reflective of inflammation in multiple sclerosis (MS). The goal of this study is to determine the feasibility of GSH measurement in MS patient and controls using widely available 3T single voxel 1H MRS and LCModel analysis. We also determined the optimal voxel placement for GSH measurements. Our results show GSH can be quantitatively and accurately measured using single voxel 1H MRS and LCModel analysis and anterior cingulate gyrus and superior temporal white matter are the ideal voxel locations for GSH measurements.

Abstract PDF Poster PDF

Keywords

absent acquisitions affects among analyzed anterior approval approximately atrophy available bandwidth better bound brain cells central channel characterization chemical chronic clinical coil complex concentration consented contributor control controls cram crucial decline defending detect determining diagnosed differ disease double enhanced feasibility filtering fits fitting gadolinium goal greater head healthy highest hospital human important improve improvements in vivo increasing index inflammation inflammatory initial instead invasive knowledge laboratory lancet lesions likely local location locations lowest major male many marker markers matched measure million minutes monitoring national nervous neurology objective optimal optimization oxidative patients people perfectly period placement plays press previous primary processes progress progressive protecting prove proven quality quantification quantified quantum radicals readily recruited relapsing related reliability reliable role saturation scanner sclerosis secondary seeing significantly since society spectral spectroscopy spectrum stage stages stress studies subject subjects suffering suggest superior suppression system table temporal thalamus tool track trends undertaken unsuppressed water week white widely women worldwide worsening