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Abstract #1092

Can Whole Brain DKI Detect Regional Changes in Multiple Sclerosis Patients?

Paulo Dellani1, Paul Bronzlik1, Refik Pul2, Martin Stangel2, Heinrich Lanfermann1, Peter Raab1

1Neuroradiology, Hannover Medical School, Hannover, Germany; 2Neurology, Hannover Medical School, Hannover, Germany

Whole brain Diffusion Kurtosis Imaging evaluation can show regional dependance of Multiple Sclerosis related changes of brain microstructure in normal appearing tissue. Sex related differences can influence data analysis and have to be accounted for.

Keywords

able accounted analyses analyzed anatomic anisotropy apparent appearing approved artifacts axial brain capsule cerebellar cerebral channel characterization clinical coefficients coil comparing complexity consented control controls corpus corrected correction correlated covariate cover coverage damage derived detect detection deviation deviations difficult diffusion diffusional diffusivity distortion distortions dual equipped estimation evaluate examined exclude feasible ferris field flair fractional future gradient head healthy hemispheres implant improve indicating instance internal investigating isotropic known kurtosis limb mainly manually martin measure measures medical medulla metal middle model motion multivariate near nerve nerves neurology noise optic overall parallel part pathologic patient patients pattern patterns peduncle peter placed positions posterior potential press pulsed quality quantification quantifying radial radiology radius reasons reduction regional related resolution rostrum scanner scanning school sclerosis several sexes side slices software spin studies table tensor tensors thalamus thereby tissue water whether whole women