Meeting Banner
Abstract #1087

Assessment of Normal-Appearing Brain Tissue Changes in Multiple Sclerosis Using Diffusion Kurtosis Imaging

Wenshu Qian1, Koon-Ho Chan2, Queenie Chan3, Henry Ka Fung Mak1

1Diagnostic Radiology, The University of Hong Kong, Hong Kong, China; 2Medicine, The University of Hong Kong, Hong Kong, China; 3Philips Healthcare, Hong Kong, China

Pathological and MRI studies of multiple sclerosis (MS) have shown that lesions are often located in both white matter (WM) and gray matter (GM), though the ones in GM are often underestimated. Diffusion kurtosis imaging (DKI) has been applied to probe the non-Gaussian diffusion property of brain tissues in vivo and proved to be less sensitive to the partial volume effects from the CSF. In this study, we demonstrate microstructural changes in normal-appearing WM and GM in MS using DKI-derived metrics, which might serve as imaging markers for early diagnosis and prognostication of the disease.

Abstract PDF Poster PDF

Keywords

acquisition adults agrees aimed anisotropy appear appearing applied assessed assessment axial best body brain calibration cause central china clinical coil complexities complexity considered control cortical cover crucial decrease decreased density derived despite detected deviation diagnosis diagnostic diffusion diffusional diffusivity dimensionless diminishing disability disease duration emerges encoding especially estimator excitation experienced extension females field former fractional frequent full gradient gray half head henry heterogeneity hong impairment includes indicated indicating inflammatory informed integrity investigation kurtosis lesions longitudinal loss maintenance male males maps markers masks medicine metric metrics minimally moderate monitoring motor neuronal nominal observer others part partial pathological patients poor potent progression prompt providing radial radiology recent reconstruction reduced resolution respectively rest revealed running samples scanner sclerosis sense sensitive seven severe shrinkage signed significantly slices smoothing spatial stroke structural studied studies subject subjects subtle suggesting supplementary surrounding system target tissue transferred transverse trend twenty ultra undersized visible volume white whole yang years young