Hongfu Sun1,
Andrew Walsh1, R. Marc Lebel1, Gregg Blevins2,
Ingrid Catz2, Jian-Qiang Lu3, Edward Johnson3,
Derek Emery4, Kenneth Warren2, Alan H. Wilman1
1Biomedical
Engineering, University of Alberta, Edmonton, Alberta, Canada; 2Division
of Neurology, University of Alberta, Edmonton, Alberta, Canada; 3Laboratory
Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada; 4Radiology
and Diagnostic Imaging, University of Alberta, Edmonton, Alberta, Canada
Brain iron accumulation occurs in multiple sclerosis (MS). Validating MRI measurements of brain iron requires postmortem study. We compare in situ postmortem quantitative susceptibility mapping (QSM) to Perls iron staining in MS subjects. High correlations were found between QSM and Perls' iron stain optical density.