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Abstract #1081

Validation of Susceptibility Mapping for Quantification of Iron in Subcortical Grey Matter in Multiple Sclerosis

Hongfu Sun1, Andrew Walsh1, R. Marc Lebel1, Gregg Blevins2, Ingrid Catz2, Jian-Qiang Lu3, Edward Johnson3, Derek Emery4, Kenneth Warren2, Alan H. Wilman1

1Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada; 2Division of Neurology, University of Alberta, Edmonton, Alberta, Canada; 3Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada; 4Radiology and Diagnostic Imaging, University of Alberta, Edmonton, Alberta, Canada

Brain iron accumulation occurs in multiple sclerosis (MS). Validating MRI measurements of brain iron requires postmortem study. We compare in situ postmortem quantitative susceptibility mapping (QSM) to Perls iron staining in MS subjects. High correlations were found between QSM and Perls' iron stain optical density.

Keywords

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