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Abstract #1078

Immune Cells in the Diffusely Abnormal White Matter of Multiple Sclerosis

Cornelia Laule1, Vlady Pavlova1, Esther Leung1, Guojun Zhao2, Piotr Kozlowski2, Anthony L. Traboulsee3, David K.B. Li2, 3, Wayne Moore1, 3

1Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada; 2Radiology, University of British Columbia, Vancouver, BC, Canada; 3Medicine (Neurology), University of British Columbia, Vancouver, BC, Canada

T-cells, B-cells and activated microglia in MS post-mortem brain tissue were examined. In general, similar levels of microglial activation, B-cells and T-cells were observed in diffusely abnormal white matter (DAWM) and normal appearing white matter (NAWM). While previous studies have reported myelin and axonal abnormalities in DAWM relative to NAWM, these abnormalities appear not to correlate with the degree of microglia activation or the presence of B or T-cells.

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Keywords

abnormal abnormalities activated activating activation affecting antibody appear appearing arch autoimmune automatic axons background boundary brain branching camera cell cells cellular central class classified clinical coil complex components consistent correlate count counted defined degree determine diffusely disability disease duration either elsewhere elucidate embedded error etiology even examined families features field fields findings five fixed formalin funding general head histochemical histological immune important individuals inspection instead intermediate known laboratory larger least lesion lesions long macrophage macrophages major manual mapped marker matrix medicine microscope mildly morphological nature nervous network neurology normally onto outlined paraffin pathogenesis pathological pathology photographed plus poorly positively post presence presentation primary process processes prognostic progressive quantified radiology ramified reduced reported resolution response responses revealed role round sample samples sclerosis secondary sectioned sections segmentation shape shaped significantly slices society stained staining statistical stimulus studies subjects support system tagging thick tissue tissues training twelve type typically undergo warranted whether white women