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Abstract #1059

The Effect of Increasing Concentrations of Intracranial Albumin on Fluid Flow Rates Within Adjacent White Matter Tracts in Rats

Carmen Kut1, Vadappuram Chacko2, Betty Tyler3, Arvind Pathak2, Zaver M. Bhujwalla4, Xingde Li1, Elliot R. McVeigh1, Daniel A. Herzka5, Stuart A. Grossman6

1Biomedical Engineering, Johns Hopkins, Baltimore, MD, United States; 2Radiology, Johns Hopkins, Baltimore, MD, United States; 3Neurosurgery, Johns Hopkins, Baltimore, 21205, United States; 4Radiology, Johns Hopkins University, Baltimore, MD, United States; 5Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States; 6Oncology, Johns Hopkins, Baltimore, MD, United States

In most systemic cancers, tumor cells are passively disseminated via flow to lymph nodes. Although the brain does not contain lymphatics, glioma dissemination in the brain may be a function of extracellular fluid along white matter tracts (WMT). Malignant brain tumors are characterized by a disrupted blood-brain-barrier that results in albumin leaking from blood vessels, which osmotically pulls water into brain. Our animal study (n = 19) shows that high albumin concentrations are positively correlated with high flow rates and MRI results are promising and provides a non-invasive method to trace WMT flow rates in patients.

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Keywords

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