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Abstract #1045

MRI Correlates of Dendrite Abnormalities in the MeCP2-A140V Mouse Model of Rett Syndrome

Gregory H. Turner1, Qingwei Liu1, Shannon L. Olfers2, Garilyn M. Jentarra3, Sampathkumar Rangasamy2, Vinodh Narayanan2

1Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, United States; 2Developmental Neurogenetics Research, Barrow Neurological Institute, Phoenix, AZ, United States; 3Biochemistry, Midwestern University, Glendale, AZ, United States

Mutations of the gene MeCP2 have been shown to cause Rett syndrome and are associated with other neurodevelopmental disorders such as autism and X-linked mental retardation. These mutations result in altered dendrite pathology and abnormal fine dendrite structure. DTI was used to measure alterations in FA in cortical gray matter in WT and MeCP2-A140V mutant mice and to evaluate its potential as a non-invasive biomarker of dendritic branching complexity.

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Keywords

aberrant abnormal abnormalities affecting altered animal animals anisotropy apical autism barrow basal biochemistry brain branches branching cause cell cerebral characterized collected correlates cortex cortical deceleration dendrite dendrites density detected development developmental difficulty diffusion directional disability disorder disorders entire evaluate examine example expressing extent fibers findings fine fractional gene genetics goal gray growth hands head histology human in vivo include indicate influenced institute intellectual invasive knock lateral lesser linked loss major maps matrix measures mental mice model months mouse mutant mutation mutations nature neurological occur packing pathological pathology patients perpendicular phenotype phoenix potential protons purposeful quantify rare resolution retard retardation revealed reveals sacrificed scanner sections slices slowing spin stained structure structures surface syndrome tensor therapies tissue tool turner type valuable visualize walking water white wild