Meeting Banner
Abstract #1043

Pharmacological MRI and Tensor-Based Morphometry in the 6-OHDA Rat Model of Parkinsons Disease

Robert Westphal1, Camilla Simmons1, Michel B. Mesquita1, Tobias C. Wood1, William R. Crum1, Denise Duricki1, Anthony Vernon2, Steve C.R. Williams1, Diana Cash1

1Neuroimaging, King's College London, Institute of Psychiatry, London, United Kingdom; 2Psychosis Studies, King's College London, Institute of Psychiatry, London, United Kingdom

Animal models such as 6-OHDA lesioning in rats are crucial for our understanding of Parkinsons disease and serve as an ideal test-bed for therapeutic interventions. In an attempt to further characterize the 6-OHDA rat, we employed pharmacological MRI and structural MRI, revealing new features such as thalamic & cortical functional impairments and structural changes in the brain stem and the frontal cortex. These results give new insights into the mechanisms of pathology in this model, which may broaden its application for novel therapeutic treatments.

Abstract PDF

Keywords

abnormality activation activations addition administered already altered apparent appear assessed asymmetry basal bilateral blue body bold brain brains bundle caused clear coincide college considered continually contraction contrast contributor control cortex cortical credence cyan days decreases degeneration depict depletion dimensions direct disease dopamine duty efferent enforces evaluate fact final five fluid frontal functional gradient hours human identify impaired impairment important indicates indicating induced injection institute integrity intervention interventions king kingdom lesion lesioned lesioning local long loop loss major male maps medial medicine might minutes model neural neuronal neurons nuclei parametric pars pathway percentage permutation pharmacological physics post presumably processed psychiatry question rats realigned realignment receptors reduced registered related relation relationship rigid scanner sensitivity serial sham shams shrinkage side slight smoothed software statistical statistically stem stronger structural studies surgery symptomatic synapse targeting targets template tensor terminals terms thalamus therapeutic tissue transmission true trust uncorrected unilateral validity variance visualizes volume volumes weeks whole wood