Dynamic MRI in the Rat Brain at 3.0 T for Measuring Permeability of the Blood-Brain Barrier in Glioblastoma Multiforme

Keywords

abnormal accounting accounts acquisition addition affects affords allows although amount anesthetized animal animals appeared arterial assisted association axis barrier blood blue body bolus bottom brain built calculation care cells characterize clinical coil coils coincident collect compartment confound continuous contrast coronal correction correlation curves dark delay dependence describe determination determine develop differential diffusion directly disruption distribution dynamic either elemental enhancement equations evaluate exhibits extracellular extract field fitting fixed fractional function gadolinium genotypes gray health heterogeneity history house hunter identify infused infusion initial injection input intact kinetic lacks length linearized locally male maps mass measuring median mild minimized minutes model models natural nearby necessary negligible neurological noise nonlinear notice open parametric partial permeability phenotype plasma post prior proposed rats reconstructions relatively removes resolution respectively response scanner seven significantly simplification since sinus solely solenoid space strengths subsequently surface susceptibility technical therapy tissue tissues tumor tumors twenty unique variability variable variations vessel volume weeks whole