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Abstract #0994

Blood Water Volume Fraction of White Matter Hyperintensities

Valerie C. Anderson1, James T. Obayashi1, Dean Peterson1, Louis P. Riccelli2, Jeffrey A. Kaye3, Joseph F. Quinn3, William D. Rooney4

1Neurological Surgery, Oregon Health & Science University, Portland, OR, United States; 2Neuroradiology, Oregon Health & Science University, Portland, OR, United States; 3Neurology, Oregon Health & Science University, Portland, OR, United States; 4Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States

The intravascular water volume fraction (pb) of periventricular and deep white matter hyperintensities (WMH) was quantified in 15 elderly subjects (70 &[plusmn] 6 yrs). Full volume 1H2O R1 maps were prepared at 7T before and at four times after gadoteridol administration. Pb maps were obtained by voxelwise fitting of tissue and blood R1 values to an equation for two-site (transendothelial) water exchange. WMHs were identified by semi-automatic segmentation of FLAIR images. Significantly increased pb in periventricular (2.6 &[plusmn] 0.6%) compared to deep (2.1 &[plusmn] 0.5%) lesions was observed, suggesting that the etiology of periventricular and deep WMHs may be different.

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