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Abstract #0976

Parametric Response Maps from DCE-MRI Predict Response to Chemoradiotherapy in High Grade Gliomas

Martin Lowry1, Lawrence Kenning1, Christopher Rowland-Hill2, Sanjay Dixit3, Shailendra Achawal4, Chittoor Rajaraman4, Lindsay Turnbull1

1Centre for MR Investigations, Hull York Medical School, Hull, UK, United Kingdom; 2Department of Radiology, Hull and East Yorkshire NHS Hospitals Trust, Hull, East Yorkshire, United Kingdom; 3Department of Oncology, Hull and East Yorkshire NHS Hospitals Trust, Hull, East Yorkshire, United Kingdom; 4Department of Neurosurgery, Hull and East Yorkshire NHS Hospitals Trust, Hull, East Yorkshire, United Kingdom

Parametric response maps are proving useful in the search for methods capable of assessing the response to treatment in a variety of tumours. We have compared the efficacy of parameter maps generated from diffusion weighted, dynamic contrast-enhanced and dynamic susceptibility contrast imaging in the early phase of chemoradiotherapy of high grade gliomas following surgery. In this scenario only the parameters Ktrans and ve were significantly able to differentiate between the responders and non responders. Lack of efficacy of ADC and rCBV may be a combined consequence of extensive tissue remodelling and non-zero values in the various brain tissue states.

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Keywords

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