Meeting Banner
Abstract #0974

Relating Physiological MR Imaging to Neurocognitive Function in Patients with Glioma

Janine M. Lupo1, Caroline A. Racine2, Angela Jakary1, Sarah J. Nelson1, 3, Susan M. Chang4, Nicholas Butowski2

1Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, United States; 2Department of Neurological Surgery, University of California, San Francisco, CA, United States; 3Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, United States; 4Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, United States

The current frameworks for understanding neurocognitive changes over time in patients with glioma are still limited, and would benefit from correlation with imaging in order to gain insight into the pathogenesis of treatment-related brain injury. We performed a pilot study that aimed to identify quantitative physiological parameters obtained from diffusion-weighted, perfusion-weighted, and spectroscopic MR imaging prior to surgery and subsequent therapy that can relate to measured neurocognitive impairment before, during, and after the course of standard treatment regimes. Perfusion parameters were most often associated with cognitive measures in general, with normal-appearing brain regions driving associations at later time points.

Abstract PDF Poster PDF

Keywords

achieve addition affected although anatomical animals applied appropriate assess assessed asset associations attention attn bands battery become becoming benefit biological biomedical brain career category cognitive coils combined complex comprehensive considered consisted copy correlation correlations coverage decline deficits delayed determine development diffusion diffusivity digit discrimination displays domain domains encoding especially evaluated exam executive explore fiber fifteen fine fluency forward function future global grade hand identify immediately injected insight integrity language leakiness learning lesion letter list magnitude major management matrix measured measures median memory minute modality months mostly motor naming neurological nine object often oral outcome patients pegs perfusion physiological pilot post potential prior processing prospectively quantitative radiation radiology rank recall recovery recruited relate related relates relating relevant remain resection saturation scores site slice span spatial spectroscopic speed story subsequent suggesting summary supported surgery systems table therapy track tracks treatment treatments tumor understanding underwent verbal vessel visual volume week weeks whether white years