Detection and Quantification of 2-Hydroxyglutarate in Gliomas with IDH Gene Mutation Using High Resolution 900MHz 1H-NMR Spectroscopy

Keywords

ability absolute accuracy acid acquisition addition alterations amplitude basic become better bottleneck bottom cancer care catholic cause chemical clinically complex concentration concentrations consistent contained contributing conversion converted dang delay depleted detect detected detection deuterium dimensional division elevated equation examined experiment expression extracts feasibility finding findings firstly fitting five flux function gauss gave gene give grade great hospital human implications institute intensities knowledge like linked measured metabolic metabolite metabolites methylene molecule multiplets mutant mutants mutated mutation mutations nature negative neurosurgery novel nuclei overlapped oxide part partially particular patient patients positive presence previous previously probe protons published pulse quantification quantify quantifying recent redissolved reflects represent representative represents resolution sample samples scanned science secondly seltzer seven several solution spectra spectral spectrometer spectroscopy spectrum status structure studies suggest supported survival sweep terms tissue tissues transients tumors twofold type vitro volume width wild yang