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Abstract #0931

Morphometric Cortical Correlates of Pain Catastrophizing Behaviour in Patients with Chronic Painful Knee OA

Hamza Alshuft1, 2, Laura Condon1, Jennifer Dixon1, 2, Robert Dineen1, Dorothee P. Auer1, 2

1Radiological and Imaging Sciences, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom; 2Arthritis Research UK Pain Centre, Nottingham, Nottinghamshire, United Kingdom

Pain is a complex subjective experience not only involving sensory component but also cognitive and emotional dimensions. People differ in their capability in coping with pain. Pain catastrophizing defined as an exaggerated negative mental set may mediate this capability as it has been consistently found to be predictive of pain outcome leading to more emotional distress and intensified pain experience. As a psychological predictor pain catastrophizing has been extensively investigated over the past years yet its mechanism is still poorly understood. Here we investigate the MRI-based morphological brain correlates of pain catastrophizing in a group of patients with painful osteoarthritis.

Keywords

actual aimed among analyses anterior application approved arthritis assess attention audience back bear best bias bishop bounds brain brought cause chronic clinical clusters coil committee completed conditions confirmed consequence consistently contribute controlled controlling coping correlates correlation cortical covariates cross curative defined design development discovery disentangle dispositional distress duration emotional emotions ethic even experience experimental explain extensively fear focally frontal furthermore fusiform going head hemisphere included individual inferior intensified interrelation investigate investigation involved isotropic kingdom knee knowledge known lagged laura liberal likelihood limbic limitation limited little longitudinal made mainly major males manage medial mediate medical mental namely negative neural neuropsychiatric package pain painful patients perspectives plastic positive posterior predict predictor predispose preliminary processing prospective psychological radiological ranging reduced reduces reflects related relation relatively residual response sample scale sciences scores secondary significance situational software studied studies suggests superior surface surfer target tendency theoretical thicker thorn thoughts threshold treatment uncorrected variations various whole year