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Abstract #0912

Altered Dorsal Attention and Default Network Connectivity Associated with Dimensional Measures of Attention-Deficit/Hyperactivity Disorder

Amanda Elton1, Sarael Alcauter1, Wei Gao1

1University of North Carolina at Chapel Hill, Chapel Hill, NC, United States

Resting-state fMRI was used to investigate alterations in functional connectivity within and between the dorsal attention and default network associated with dimensional and categorical measures of ADHD in 195 children with ADHD and 241 typically-developing children. Symptoms of inattention and impulsivity were associated with greater functional connectivity in the dorsal attention network. Symptoms of inattention were also associated with diminished functional competition between the two networks. Impulsive symptoms were associated with diminished functional competition between regions of the dorsal attention and default network in typically-developing children, but this brain-behavior relationship was disrupted in ADHD.

Keywords

abnormalities academy activity altered analyses anti application association associations attention attentional audience behavior behavioral behaviors believed best beyond brain categorical chapel characterize characterizing children clinical cognitive combination combined competition compromised conditions connectivity contribute correlation cortex default deficit defined demanding detect developing diagnoses differential dimensional diminished directed disorder disorders displays disrupted disruptions domains dominant dorsal driven dynamic dysfunctional etiology evaluating exist externally find fluctuations functional furthermore generally greater healthy hill human hyperactivity hypotheses hypothesis hypothesized impaired impairments implicated impulsive inappropriate inattention individual integration inter interfere internal intrinsically introspective investigate investigations likewise linear manifest measures mechanism medicine middle model national network networks neural neuronal north organized parietal pathological patient pertinent plausible populations posits potential proceedings processes prone referential regression related relationship relationships relevance researchers resting revealed sample scale scales sciences seed self sensitivity sought spontaneous suggest superior support supports symptoms synchronization systems target tasks temporal theory treatment trends typically underlie utility