Meeting Banner
Abstract #0898

Towards a Connectome Mapping Pipeline for Neonates Using High-Resolution MP2RAGE and DTI

Andreina Pauli1, Juliane Schneider2, Meritxell Bach Cuadra, 13, Alessandra Griffa, 13, Elda Fischi Gomez3, Reto Meuli1, Jean-Philippe Thiran, 13, Anita C. Truttmann2, Patric Hagmann, 13

1Department of Radiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland; 2Clinic of Neonatology, University Hospital Center and University of Lausanne, Lausanne, Switzerland; 3Signal Processing Laboratory (LTS5), Ecole Polytechnique Fdrale de Lausanne (EPFL), Lausanne, Switzerland

Mapping the human connectome in neonates is a real technical challenge in many respects. We use high resolution MP2RAGE and a combination of freely available tools to segment and partition the cortex automatically. In combination with DTI tractography, the brain segmentation is used to map the neonatal connectome. Our connectome mapping pipeline is tailored for neonatal images and allows us to calculate a structural connectivity matrix, while exploiting the advantages of MP2RAGE sequence.

Keywords

able accurate acknowledgments acquisition advantageous advantages already analyzing anatomical assign assigned atlas available bias born brain brains channel classification clinic coil complex computed connected connecting connectivity considered contrast contrasts core correcting cortex cortical create created dale dedicated default derived differentiation diffusion double endpoints equivalent errors excellent exists exploit exploiting exploring fiber fibers final foundation foundations fractional free functional furthermore gestational gradient grant hand head hospital identify infant initial intensity inversion isotropic just labeling labels laboratory least located manipulated manually mapping maps marques mask masks material matrix methodological mode motion much native necessary needs neonatal neonate neonates pair pilot pipeline plot preexisting prematurely previously probabilistic process processing providing radiology rage reconstruct reconstruction refocused registration resolution respective rigid robust scanned segment segmentation since skull slices smith spatial step steps streamline stripped stripping structural surface surfaces tailored template templates term threshold tissue tool toolkit topological towards twice upstream usable useful varying vertical volumes white