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Abstract #0893

On the Comparability of Volumetric Brain Data in the Multicentric IMAGEN Study

Rdiger Brhl1, Albrecht Ihlenfeld1, Semiha Aydin1, Penelope A. Gowland2, Gareth John Barker3, Tomas Paus4, Jrgen Finsterbusch5, Simone Khn6, Jrgen Gallinat7, Arun Bokde8, Michael Smolka9, Frauke Nees10, Jean-Luc Martinot11, Gunter Schumann3, the IMAGEN Consortium3, Bernd Ittermann1

1PTB, Berlin, Germany; 2University of Nottingham, Nottingham, United Kingdom; 3Institute of Psychiatry, Kings College London, London, United Kingdom; 4Rotman Research Institute, University of Toronto, Toronto, Ontario, Canada; 5University Medical Center Hamburg-Eppendorf, Hamburg, Germany; 6Max-Planck-Institut fr Bildungsforschung, Berlin, Germany; 7Psychiatry and Psychotherapy, Charit Universittsmedizin, Berlin, Germany; 8Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland; 9Department of Psychology, Technische Universitt Dresden, Dresden, Germany; 10Central Institute of Mental Health, Mannheim, Germany; 11University Paris Descartes, Paris, France

The multicentre study IMAGEN scanned more than 2000 at 8 sites in Europe using scanners of 4 different manufactures. Freesurfer's volumetric results show significant differences between the sites and especially the scanner models. Data of phantoms and 2 traveling volunteers are used to explain these differences leading to the necessity of characterizing the gradient induced distortion field locally. Data of 2 new precision geometry phantoms will provide the information to finally decide whether the differences are artificial or sample generated.

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Keywords

accelerated acquisition adolescents adults analyzed anatomic anatomical applied applying artifact assessment assumed attention barker bars became behavior bench block bore bores brain central clear coil college completed consortium constant contrast control coronal correct corrected correction corrections cubic cylindrical dale datasets deviation distortion distortions error especially even excite exist explain extended female geometrical geometry grid hamburg head health healthy highly improved inadequacy increasing indeed indicate indicates induced inequalities initial inserts institute instrumental investigation issue king kingdom local machined made male manufacture manufacturer measured measures mental mesh middle midst much normalized output percent periodically perspex phantom phantoms posteriori precision procedure project psychiatry psychology psychotherapy quality question real receiver reconstruction reflecting relevant reproducibility risk robust ruled scanned scanner selected sense several site sites sobering software solid stage standardization still structural studies subgroups subject subset susceptibility table teenagers tentatively trinity ultimately variation variations varies vary volume volumes volumetric volunteer volunteers water weeks whenever whether widely