Meeting Banner
Abstract #0883

Theragnostic Imaging of Micelle-Mediated Rosiglitazone Delivery to Atherosclerotic Plaques

Brigit den Adel1, 2, Sandra Bovens3, Ernst Suidgeest4, Gustav J. Strijkers5, Gerard Pasterkamp3, Robert E. Poelmann2, Louise van der Weerd6, 7

1Pathology, Amsterdam Medical Center, Amsterdam, Netherlands; 2Anatomy, Leiden University Medical Center, Leiden, Netherlands; 3Cardiology, University Medical Center Utrecht, Utrecht, Netherlands; 4Radiology, Leiden University Medical Center, Leiden, Netherlands; 5Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands; 6Radiology , Leiden University Medical Center, Leiden, Netherlands; 7Human Genetics, Leiden University Medical Center, Leiden, Netherlands

This study shows the theragnostic imaging and treatment of atherosclerotis in ApoE-/- and ApoE-/-eNOS-/- mice. The application of non-invasive molecular imaging to monitor drug delivery and therapeutic responses. Rosiglitazone was incorporated in micelles to improve targeting to plaques and reduce the well-known side effects of this drug. Atherosclerotic lesions were reduced after micelle-mediated rosiglitazone therapy, while avoiding the negative side effects associated with conventional rosiglitazone treatment.

Abstract PDF Presentation Video

Keywords

accumulated administration allowed analyses anatomy animals anti aortic application applied arch arteries assess assessment atherosclerosis biomedical bore cardiac cardiology carotid causing cholesterol considerable contrast control controls controversial correction correlation delivered delivery determine determined developed deviation diabetic diet disease divided done drawing drug effective efficacy enable engineering enhanced expected film flash formulation gadolinium gain gated genetics genotypes good histological histology human hydration improve in vivo included incorporating inflammatory inhibited initially known labeled lesions lipid load longitudinally macrophage mediated medical mice micelles mini molecular monitor morbidity mortality muscle negative noise noninvasive objectives oral osmotic pathology period plaque plaques plasma post potential preferentially prepared progression pumps radiology randomly reducing reduction reported represented responses responsive retrospectively selected severity side significance sites specifically statistical surrounding surviving system targeting technology therapeutic therapy treated treatment validated variance vertical vessel visible vitro wall weeks western whether world