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Abstract #0818

Single-Breath Gas and Dissolved-Phase 129Xe MRI in Healthy Subjects Using a 3D Radial Sequence: Effect of Posture on Signal Distribution

Suryanarayanan S. Kaushik1, 2, Matthew S. Freeman, 23, Zackary I. Cleveland, 24, Rohan S. Virgincar2, Scott H. Robertson, 23, John Davies5, Jane Stiles6, William Michael Foster6, H. Page McAdams4, Bastiaan Driehuys2, 4

1Biomedical Engineering, Duke University, Durham, NC, United States; 2Center For In Vivo Microscopy, Duke University, Durham, NC, United States; 3Medical Physics Graduate Program, Duke University, Durham, NC, United States; 4Radiology, Duke University, Durham, NC, United States; 5Respiratory Therapy, Duke University, Durham, NC, United States; 6Pulmonary Medicine, Duke University, Durham, NC, United States

In addition to its alveolar gas-phase resonance (0 ppm), 129Xe dissolved in the pulmonary tissues gives rise to distinct resonances in the barrier tissue (197 ppm) and red blood cells (211 ppm). To quantify this dissolved 129Xe distribution, the gas-phase image should be acquired in the same breath. To this end, we describe an interleaved 3D-radial acquisition that acquires isotropic images of both the dissolved and gas-phase 129Xe. Using this acquisition, we probe the effect of the supine and prone posture on the dissolved-phase signal distribution.

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Keywords

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