Lactate and Pyruvate as Mediators of Metabolic Cooperation Between Stromal and Breast Cancer Cells

Keywords

acidification acidifying acknowledge acquisition added aerobic alone amounts analyses applying arch assayed attachment availability bone bottom breast buffer butyrate calf cancer cell cells cellular chamber chem conditioned containing convert cooperation counter culture cultured days decays decoupled defective delay derived development dimethyl done efflux either energetic enhanced epithelial exchanged expelling exponential exposed exposure express expression extracellular extract extracts extrusion favoring fetal fibroblasts free fuel fund glucose grant growth harvested incubated incubation indicate indicated induced induction intracellular invasion invest investigated john labeled lactate limited maintained marrow materials measure media mediators medium membranes metabolic metabolize metastatic molecular needs neighboring nutrients oxidative oxidatively passage penicillin plasma plate plated play plus potency precursors predominantly presence prevents previously production progression proliferation proliferative quantified reprogramming response role secrete secreted seeded serum sigma significantly spectra spectral spectrometer spectroscopic stem streptomycin subsequently suggested suggesting supplemented supplied support supporting take taken thereby thrice transformed transporters tumor tumors uniformly uptake valuable washed