Meeting Banner
Abstract #0796

Brain Microstructure Assessed by CHARMED and NODDI in the Newborn

Nicolas Kunz1, Hui Zhang2, Yaniv Assaf3, Franois Lazeyras4, Daniel Alexander2, Petra Susan Hppi1, 5

1Pediatrics, University of Geneva, Geneva, Switzerland; 2Computer Science, University College London, London, United Kingdom; 3Neurobiology, Tel Aviv University, Tel Aviv, Israel; 4Radiology-CIBM, Geneva University Hospitals, Geneva, Switzerland; 5Department of Neurology, Childrens Hospital, Geneva, Switzerland

Diffusion tensor imaging (DTI), may be the only feasible technique to study micorstructural changes occurring during the brain development. The main aims of this study was to design a complete new pipeline to perform micro-structural diffusion analysis in neonatal brain and to compare DTI to CHARMED and NODDI, which provides new microstructural metrics such as the intra-axonal volume fraction (VFia). High quality subject template was generated using DTI-TK tensor registration tools, which allows the accurate definitions of 13 ROIs. FA and VFia were able to depict fine mircostructural differences in early maturation fiber tracts.

Abstract PDF Presentation Video

Keywords

able accurately acquisition addition additional additionally agreement alignment alternative anisotropy anterior apart appears appropriate assessed attractive axial basis body brain capsule cellular charmed children choice clearly committee compartment compensates compute computer conducted consistent contrast cook corpus correspond density despite developed development differentiates diffusion diffusivity disabilities dispersion double drawn expect explains external extra fanning fiber fibers finally findings finds fitting fixed foundation fraction future generate geometry gestation gestational good gray great hence highest identification include indeed internal intra investigates isotropic kingdom known lack last leads limb literature local maps measure measures media model models modest much neurobiology neurology newborn newborns occurring ones ongoing organized orientation original packing pediatrics periods plausible posterior pregnancy presence pronounced providing pulse radiation radiology reasonable reconstructed remaining respectively scalar scanned scheme science separate separately separation shells similarly space spatial specificity stages subject subjects system table template tensor term terms tightly tools tracts trend trimester visible volume weeks white