Meeting Banner
Abstract #0776

Tractography with Physiology Rendering of Human Brain Using Diffusion Basis Spectrum Imaging

Yong Wang1, Peng Sun1, Fang-Chang Yeh2, Robert Naismith3, 4, Anne H. Cross3, 4, Sheng-Kwei Song1, 4

1Radiology, Washington University in St. Louis, Saint Louis, MO, United States; 2Departments of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, United States; 3Neurology, Washington University in St. Louis, Saint Louis, MO, United States; 4Hope Center of Neurological disorders, Washington University in St. Louis, Saint Louis, MO, United States

Diffusion tensor imaging (DTI) has been successfully used to quantify directional diffusivities of coherent white matter tracts and perform tractography. However, DTI cannot model crossing fibers and subvoxel partial volume effect due to increased cellularity and extra-cellular space. Diffusion basis spectrum imaging (DBSI) has recently been proposed to overcome DTI limitations. Preliminary phantom and animal studies have suggested that DBSI not only resolved crossing fibers, but also computed directional diffusivities of each crossing fiber and quantified subvoxel partial volume effect. In this study, we reported the first application of DBSI to normal human brain and demonstrated DBSI utilities mapping white matter connectivity and quantifying multiple diffusion components along fiber tracts.

Abstract PDF Presentation Video

Keywords

account accuracy addition address advanced although analyzed anisotropic another applied approaches approved arrows axial basis biomedical board boxes brain brains capable cells central clinical component components computed conducted confounding conjunction connection consistently contamination contrast corona corpus correctly cross crosses crossing dataset density derived detect detected detection determined diffusion diffusivity directional disorders edema edge engineering entirely estimating example extent extra extracellular facilitate fiber fibers fitting form fractions fully generalized generated global gray green grid grids healthy highest hope human improve inflammation informed injury institutional isotropic limitation located loss measured minutes model modeling much nervous neurological neurology none nonlinear nonnegative onto optimization orientation orientations original partial pilot proposed quantified quantify radial radiology recommended reconstructed reduced reflected rendered rendering resolution respectively review saint sampling scanner scanning search solved song space specificity spectrum still subject successfully superior surfaces surrounding system taken tensor tissue tract tracts translation transverse turning upward various ventricle visualized volume white whole