Meeting Banner
Abstract #0751

Deep Brain Stimulation at the Internal Globus Pallidus Produces fMRI Response in the Motor Cortex

John Robert Younce1, Hsin-Yi Lai1, Yen-Yu Ian Shih1

1Experimental Neuroimaging Laboraory, Department of Neurology and Biomedical Research Imaging Center, UNC Chapel Hill, Chapel Hill, NC, United States

This study demonstrates significant response in the motor cortex as a result of deep brain stimulation at the internal globus pallidus. The BOLD responses occur bilaterally in a frequency-dependent manner, with positive responses in the ipsilateral motor cortex peaking at high frequencies (100 Hz), and negative responses in the contralateral motor cortex peaking at low frequencies (40 Hz). These frequencies generally correspond to those producing improvement and exacerbation, respectively, of parkinsonian symptoms in humans and animal models, making this technique potentially powerful for exploration of cerebral changes in DBS in parkinsonian animal models.

Abstract PDF Presentation Video

Keywords

according acquisition activation activity addition aimed allowed although amplitude anesthesia animals around atlas axons bilateral bilaterally biomedical bold boxes brain capsule cause chapel characterize chosen circulated clinical clinically coil common compatible concentrated conduction corrected cortex cortical crucial deep degree delay dental dependent direct disease double durable efferent efferents electrode epoch etiology exacerbation excitatory exhibit experimental fisher fixed frequencies frequency future hemisphere hill home hours hypothesized hypothetical indicate indicating ineffective inhibition initial inter internal intubated involvement known limiting maintain male manner maps mechanism mechanisms mechanistic motor much nearby negative neurological neurology noted optimize paradigm patterns peaked peaking physiological pilot placed placement population positioned positive posterior potential previously procedure produce pulse random rats response responses responsible rest resting scale science section sends setup significance smoothing stability statistical still stimulation stimulus studied subject suggesting suggests surface symptomatology symptoms synapses system targets temperature temporal therapeutic tonic treatment trends trial ventilation ventral visible wave width yellow