Meeting Banner
Abstract #0745

Bone Marrow Uptake of Ferumoxytol: A Preliminary Study in Healthy Human Subjects

Pippa Storey1, Arnaldo A. Arbini2

1Radiology Department, New York University School of Medicine, New York, NY, United States; 2Department of Pathology, New York University School of Medicine, New York, NY, United States

Ultrasmall superparamagnetic iron oxide (USPIO) particles are macrophage-specific contrast agents, which hold promise for identifying bone marrow lesions. This preliminary study in healthy adults investigated marrow uptake of ferumoxytol (Feraheme), a USPIO agent that was recently approved for human use in the United States. Images were acquired before and 3 days after intravenous ferumoxytol administration, using a multiple gradient echo sequence that allowed simultaneous quantification of fat:water ratios and T2*. Results suggest efficient uptake of ferumoxytol by hematopoietic marrow, with less uptake by fatty marrow. Further studies are needed to investigate the utility of this technique in differentiating marrow lesions.

Abstract PDF Presentation Video

Keywords

absorption accounted administration adults agent ages aliasing among apparent appears approved assessment assumed became body bone bottom calculation certain chosen closely coincide complex components composition conditions considerable content contrast coronal correlation correlations criteria days decay deficiency defined despite differentiating distribution domain efficiently evaluated example except exhibit expected fatty fitting five fraction generated gradient gradients graphs greater half healthy history hold human humans included increasing indicated inflammation informed injection inspection intravenous investigate iron isotropic label lesions lipid local loss macrophage maps marrow matches maximize medicine menopausal minimal model needed neoplasms overload oxide participate particles partitions pathological peak peaks persistent pharmaceuticals pixel plasma poor positive post potential pregnancy preliminary prevent principal procedure promise protocol proximal quantify radiology rapid reaction reactions readout reconstructed reported residual resolution respectively response responses revealed rigid rodents school significantly simultaneous since slice spacing specificity spectral sterile studies subcutaneous subject subjects sufficient suggesting taken transformation treatment uptake versus water year