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Abstract #0735

Cortical Thickness Revealing Cerebral Anatomical Deficits in Drug-Naive First-Episode Schizophrenia

Yuan Xiao1, Su Lui1, Li Yao1, Teng Xie2, Yong He2, Qiyong Gong1

1Department of Radiology, Huaxi MR Research Center,West China Hospital, Chengdu, Sichuan, China; 2State Key Laboratory of Cognitive Neuroscience and Learning,Beijing Normal University, Beijing, China

Synopsis:Cortical thickness was measured to investigate the anatomical deficit in antipsychotic naive first episode schizophrenia. 128 patients and 141 healthy controls were recruited. We employed CIVET software to extract cortical thickness measurements from T1-weighted MRI images. The cortical thinning, especially, the right dorsolateral prefrontal cortex, may be resulted from neuroprogression in schizophrenia. Cortical thickening in bilateral temporal poles and other cortices were also revealed and may result from the compensatory mechanism or abnormal neurodevelopment at early stage of schizophrenia. In addition, a strong link between PANSS scores and cortical thickness displayed a consensus between cerebral structure and clinical manifestations.

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Keywords

aberrations abnormal activation addition alterations analyses anatomical approved archives arrangement array association beginning believed besides bilateral blue cerebral characteristics characterized china circuits civet clinical clusters cognitive coil combination committee complex consensus control controls correction correlated correlation correlations cortex cortical cortices covariance deficits degree density depression disconnection discovery disease displayed disturbance drug employed episode especially ethical evidences examination exhibited explain explore explored extract facilitate features fibers function functioning furthermore general genetic global gong gray head healthy hospital identified important inconsistent informed investigate involving laboratory largest learning lifetime link local longitudinal mainly manifestations mantle many measures mechanism medial naive nerve neurological neurons patient patients patterning performances pole poles positive previous process psychiatry psychopathology quite radiology reduced reflects related relatively represents reveal revealed sample scale schizophrenia scores significance significantly software strong structural structure studies subjects support surface symptoms syndrome system table tailed temporal thickening thinning though thought together trajectory vertex volume west written yuan