Meeting Banner
Abstract #0712

Whole Brain Arterial Transit Times in the Elderly Estimated Using Arterial Spin Labeling

Henri J.M.M. Mutsaerts1, Edo Richard2, Dennis F.R. Heijtel1, Charles B.L.M. Majoie1, Aart J. Nederveen1

1Radiology, Academic Medical Center, Amsterdam, Netherlands; 2Neurology, Academic Medical Center, Amsterdam, Netherlands

Transit time measurements may not only improve the quantification of arterial spin labeling but also provide valuable diagnostic information that is unavailable with cerebral blood flow measurements alone. This study estimates micro-vascular arterial transit time by Flow-Encoding Arterial Spin Tagging (FEAST) in a large sample of community-dwelling elderly. The measured transit times show a consistent spatial pattern and depend on age and gender. If no transit time maps are available, our linear regression parameters provide an alternative to a fixed transit time.

Keywords

ability academic added addition aged aims alone alternative although analyses anterior arterial assoc asymptomatic available background blood blue border brain capture care cerebral clinical coefficients community compartment computed confirm confounder consecutive consistent continuous coronal correlated crushed crushing define delay dementia described diagnostic disease diva drawn duration dwelling efficient elderly encoding equation essential estimation evaluate exists feast fixed flow furthermore gender green healthy highest impairment include includes influence input intensive inter intercept investigate investigating labeling linear longer macro major male maps mater measured medical micro middle minutes model neurology noise onset pathology pattern physiologic population post posterior prevent previously proposed protocol pseudo quantification quantify radiology rationale refer regression representing resolution respectively retain sample scanning seem seems sensitive significantly slice slices spatial spin subjects substantial sufficient summarizes suppression table tagging temporal territory transit transversal unavailable valuable variation vascular vessel volunteers watershed whether whole years young