Meeting Banner
Abstract #0691

Multi-Parameter Quantitation of Coincident Fat and Water Skeletal Muscle Pathology

Christopher D.J. Sinclair1, 2, Jasper M. Morrow1, Robert L. Janiczek3, Michael G. Hanna1, Mary M. Reilly1, Tarek A. Yousry1, 2, Rebecca S. Samson4, Nikolaus Weiskopf5, Antoine Lutti5, David L. Thomas2, Xavier Golay6, John S. Thornton1, 2

1MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology, London, United Kingdom; 2Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom; 3United Kingdom, GlaxoSmithKline, Brentford, Middlesex, United Kingdom; 4Department of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom; 5Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, United Kingdom; 6Department of Brain Repair and Rehabilitation, University College London, London, United Kingdom

Quantitative imaging of skeletal muscle may provide important markers of disease for clinical trials. We used quantitative magnetization transfer (qMT) imaging and the IDEAL-CPMG fat-water separation method to quantify the muscle water-component T2 relaxation times and muscle fat-fraction in the calves of patients with inclusion body myositis. A range of pathologies were observed including isolated T2 elevation, isolated fat-fraction increases or both. QMT parameters, such as the bound pool fraction f, reflected the variations and f was decreased in muscle displaying isolated edema. Further investigation of these relationships may allow the identification of muscles involved early in the disease.

Abstract PDF Presentation Video

Keywords

accompanying actual allows amplitudes anatomical appeared appearing approaches array beneficial body bound brain calf central characterize chosen chronic clinical coil coils coincident combinations combined common complicates component compound confounding consistent correction decreased degeneration derive despot determine disease drawn early echoes edema edematous elevated elucidate equally examinations examined example exhibiting expected feature field findings fits fitted flash fraction free future generating genuinely gives great healthy heterogeneous ideal identify identifying imminent important inclusion infiltration inflammatory influence injury insight institute interactions interpretation investigated isolated jasper john kingdom magnetization maps marker markers matrix mode modeling morrow muscle muscles neurology neuromuscular occur offset pathological pathology patient patients percentage pool populations practical preceding presence previous process processed providing pulse pulses quantification quantifying quantitative registered rehabilitation repair representative resolution response reversible selected separation skeletal slabs slice spaced spectrum studies surface table target tissue together track transfer transmit treatment trials trio trust type unequivocally units variability variable view water