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Abstract #0631

Wall Shear Stress Distribution in Carotid Artery Stenosis: Changes Pre- And Post-Intervention by Carotid Endarterectomy

Michael Markl1, Sebastian Berg2, Alex J. Barker1, J Schllhorn2, Martin Schumacher2, Cornelius Weiller2, Andreas Harloff2

1Northwestern University, Chicago, IL, United States; 2University of Freiburg, Freiburg, Germany

Low wall shear stress (WSS) and high oscillatory shear index (OSI) have been linked to the development of atherosclerosis. The purpose of this study was to investigate the impact of carotid endarterectomy on the in-vivo WSS and OSI distribution in the carotid bifurcation. In 20 patients, 4D flow MRI was able to selectively quantify regional 3D hemodynamics in patients before and after intervention for high-grade ICA stenosis. Plaque removals lead to significant reductions of WSS and OSI in the ICA while wall parameters in the CCA and ECA remained largely unchanged demonstrating a localized impact of endarterectomy on carotid hemodynamics.

Keywords

academic addition affects aimed allowed alterations altered angiography aorta artery atherosclerosis axial barker begins bifurcation blood bulb cardiovascular carotid centimeter circulation closest cohort collaborative common complex concentrated confined consequently consisted contrast covering criteria critically decrease decreased defined demonstrating development dilated directly disease distal distances distribution enhanced evaluated evaluating excellence extent female flight flow former friction global grade gradients grant hypothesized illustrates in vivo included index indicates indicating individual influence internal intervention investigated known largely lateral lead length linked local localized located location locations longitudinal lumen magnitude measurable measure medicine model models morphology mostly narrowing northwestern opposite patient patients peak physiologically plaque position positioned positions post posterior postoperative preoperative preserved previous prior program progression prospectively proximal received reduced reduction reductions removal resolution resolved segmental segments selectively sensitivity shear significantly site spatial stress stroke studies substantial substantially support surgery systolic tapering temporal therapy tool treatment typical unclear undergoing underwent variable velocities velocity vessel wall years