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Abstract #0619

Characterization of CMRO2, Resting CBF, and Cerebrovascular Reactivity in Patients with Very Early Stage of Alzheimers Disease

Binu Panjikattil Thomas1, 2, Min Sheng1, Benjamin Tseng3, Peiying Liu1, Kristin Martin-Cook4, Munro Cullum5, Myron Weiner5, Benjamin Levine3, Rong Zhang3, Hanzhang Lu1

1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; 2Department of Bioengineering, University of Texas Southwestern Medical Center/University of Texas at Arlington, Arlington, TX, United States; 3Institute of Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, TX, United States; 4Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, United States; 5Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, United States

Early-Mild-Cognitive-Impairment (MCI) represents a pre-clinical form of Alzheimers Disease (AD). In this study, we used several MRI modalities to characterize the neurobiology in early-MCI. We first used a novel technique to measure the brains energy budget, denoted by cerebral metabolic rate of oxygen (CMRO2), and observed that early-MCI showed 12.7% reduction compared to age-matched controls. Next, we used regional CBF to probe regions with most pronounced deficit and identified precuneus/posterior-cingulate as the foci. Finally, we compared cerebrovascular reactivity between MCI and control groups, data suggest that reactivity in early-MCI was relatively intact, indicating a metabolic/neural cause for the CBF deficit.

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Keywords

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