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Abstract #0613

Structural Neuroimaging Phenotype of Dementia in Adult Survivors of Childhood ALL

Wilburn E. Reddick1, John O. Glass1, Nan Zhang2, Ronald C. Peterson3, Larry E. Kun1, Ching-Hon Pui4, Melissa M. Hudson4, Leslie L. Robison5, Kevin R. Krull5, Gregory T. Armstrong5

1Radiological Sciences, St. Jude Children's Research Hospital, Memphis, TN, United States; 2Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, United States; 3Neurology, The Mayo Clinic, Rochester, MN, United States; 4Oncology, St. Jude Children's Research Hospital, Memphis, TN, United States; 5Epidemiology & Cancer Control, St. Jude Children's Research Hospital, Memphis, TN, United States

The objective of this study was to determine whether neuroanatomical characteristics of dementia were associated with memory impairment in a unique cohort of 85 long-term survivors of childhood acute lymphoblastic leukemia treated with cranial irradiation. Patients were 27-51 years of age (mean 36.5&[plusmn]6.2 years) at the time of imaging. Survivors with memory impairment demonstrated a structural neuroimaging phenotype characterized by elevated diffusivity in the temporal-parietal memory network, atypical cortical thinning of the medial orbito-frontal and parietal regions, and smaller hippocampal volumes in regions CA2-3 and CA4-Dentate Gyrus consistent with early aging and increased risk for additional memory impairment.

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Keywords

abbreviated acute adjusted adult adults aging approved assess assessed assessment atlas atypical auditory axial bilateral biostatistics body brain brief calculations cancer cancers characteristics characterized childhood children clinic cognitive cohort collinear composite conducted consistent control corrected cortical cortices cranial decades defined delayed dementia determine diffusion diffusivity early eighty elevated epidemiology evaluate evaluated every exam five flair fractional front frontal function glass global gradient gray growing hospital immediate impaired impairment improved injury integrity intensity inverse john least leukemia lobe lobes loss malignancy maps mayo measure measures medial medical memory network neurology objective occipital oncology onset parametric parietal patients pediatric phenotype placing population prevalence processed prospective radial radiation radiological reduce reduced registered registering reserve resolution risk scale sciences score segmented sets significantly smaller software space status structural subjects surfer survivor survivors system systems temporal tensor therapy thinner thinning tissue toolkit treated trial trio twelve unimpaired visual volume volumes whether white whole wise years young