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Abstract #0596

Early DWI in Assessing Tumor Response in Locally Advanced Cervical Cancer: Is There a Role in 3D MRI Guided Brachytherapy?

Keyanoosh Hosseinzadeh1, Amir A. Borhani1, Sushil Beriwal2, Peyman Kabolizadeh2

1Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA, United States; 2Radiation Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, United States

Purpose: evaluate the utility of gadexotate-enhanced MRI for detecting HCC in patient with liver cirrhosis who have T1-weighted hyperintense lesions. Method: 31 nodules were evaluated. Diagnostic performance of dynamic vs. dynamic and HB phase, Cohen statistics for interobserver agreement, bootstrap resampling technique for comparing lesion size, and fisher exact test for correlation between HB phase and histology were performed. Conclusion: the addition of HB phase did not improve diagnostic performance; however, our data shows that nodules demonstrating both precontrast T1 hyperintensity and HB phase hypointensity are malignant and there is a statistically significant size difference between benign and malignant lesions.

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