1Medical
Biophysics, University of Western Ontario, London, Ontario, Canada; 2Robarts
Research Institute, University of Western Ontario, London , Ontario, Canada; 3Physics
and Astronomy, University of Western Ontario, London, Ontario, Canada; 4Physics
and Astronomy, University of Western Ontario, London , Ontario, Canada
In chemical shift imaging, eddy current induced phase errors in the first echo of multi-echo fat-water separation techniques result in clinically significant biases in the estimates of proton density fat fractions (PDFF). Previously, this bias has been removed by modifying the reconstruction at a cost of reduced noise performance. Instead, we propose using additional gradient pulses to induce similar eddy currents for all echoes. The proposed modification to the pulse sequence was tested on the liver of a healthy volunteer and showed reduced bias in PDFF.