Meeting Banner
Abstract #0549

Eddy Current Compensated IDEAL

Trevor P. Wade1, 2, Curtis N. Wiens3, Charles A. McKenzie1, 4

1Medical Biophysics, University of Western Ontario, London, Ontario, Canada; 2Robarts Research Institute, University of Western Ontario, London , Ontario, Canada; 3Physics and Astronomy, University of Western Ontario, London, Ontario, Canada; 4Physics and Astronomy, University of Western Ontario, London , Ontario, Canada

In chemical shift imaging, eddy current induced phase errors in the first echo of multi-echo fat-water separation techniques result in clinically significant biases in the estimates of proton density fat fractions (PDFF). Previously, this bias has been removed by modifying the reconstruction at a cost of reduced noise performance. Instead, we propose using additional gradient pulses to induce similar eddy currents for all echoes. The proposed modification to the pulse sequence was tested on the liver of a healthy volunteer and showed reduced bias in PDFF.

Keywords

abdominal abstract accurately acknowledge additional affected allow applications approaches approval astronomy audience authors back bias biased biophysics cardiac chairs channel chemical clearly coil compensate compensated compensating complex consent corrected datasets degraded demodulated density echoes eddy error errors ethics evaluation expected extend fitting fraction fractions frequency gradient gradients helpful hepatic hybrid hypothesize ideal immediately improved in vivo inconsistencies induced informed initial insensitive instead institute invasive investigating known lead length liver loss many matrix measure medical minimize minimized modifications modifying noise optimal part past performance phantom physics played precedes preceding program propose proton pulse quantification quantitative quite readout reconstructed reconstruction reconstructions reduce reducing removed required researchers sensitive significantly slice subsequent support switched target targeted thank theory towards train variant volunteer wade water waveform western whenever