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Abstract #0538

Quantification of T1 Relaxation Times and Nuclear Overhauser Effect of 31P Metabolites in the Human Prostate at 7T

Miriam W. Lagemaat1, Marnix C. Maas1, Eline K. Vos1, Thiele Kobus1, Andreas K. Bitz2, 3, Mark J. van Uden1, Stephan Orzada2, 3, Arend Heerschap1, Tom W.J. Scheenen1, 2

1Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands; 2Erwin L. Hahn Institute for Magnetic Resonance Imaging, Essen, Germany; 3Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany

We assessed T1 relaxation times of 31P metabolites in the human prostate and evaluated the nuclear Overhauser effect (NOE) as signal enhancement strategy for 31P MRSI of the prostate at 7T. T1 relaxation times were found to be relatively long compared to other human tissues at 7T. To obtain a 3D 31P MRSI dataset within a clinically acceptable measurement time (TR ≤ 1.5s) with optimal SNR per unit time, a strongly reduced flip angle (≤ 45) is required. Signal enhancement by irradiating the water resonance to obtain NOE was successful, yielding up to 42% more signal for PE.

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Keywords

acceptable acquisition adiabatic agreement ahead although apparent approaches arbitrary array assigned assignment background bandwidth bladder body brain cancer channel chemical citrate clinically coherence coil combination comparable compartments concentrations considered constituents contains continuous corrected dataset determination diagnostic efficiency efficient energy enhancement evaluated even example except excitation exists experiment explored field fits fitting healthy human improve in vivo included induced inhomogeneities intensity irradiation larger limited limits listed localization long longer maps mark maximized measured median medical metabolite metabolites minutes muscle nearly nominal nuclear nuclei optimal optimization optimized partial passage patients peaks polarization positive power prevented previously print profile progressive prostate protocol published pulse pulses radiology reached recorded reduce reduced reflect refocusing related relatively relevant report reported required resolved resonate respectively ruled safety saturate saturation selective sensitivity separate settings shimming slice space spatial spectra spectroscopic spins strategy strength subject subjects suppresses surroundings system table tissue tissues tuned uncoupled unit variable variation vitro volunteer water wave whole