Meeting Banner
Abstract #0531

Indirectly-Detected Heteronuclear MR Spectroscopy & Imaging by Amplified Solvent Proton Signals

Zhao Li1, Jamie D. Walls1, Susie Y. Huang1, Yung-Ya Lin1

1Chemistry and Biochemistry, UCLA, Los Angeles, CA, United States

A general spin amplification scheme is developed to enhance the sensitivity of heteronuclear MR spectroscopy and imaging based on dynamic instability of the solvent proton magnetization under collective feedback fields of radiation damping and the distant dipolar field. The heteronuclear solute spins are first detected by the solvent proton spins through various magnetization transfer mechanisms and serve as small input signals to perturb the solvent proton magnetization, which is prepared in an unstable state. The weakly detected signal is then amplified through subsequent nonlinear evolution of the solvent proton magnetization to achieve 10x SNR improvement for 13C NMR and MRI.

Abstract PDF

Keywords

accelerate acetone achieved action aids amplification amplified amplifier amplify amplitude application audience axial biochemistry bulk capillary carries carrot chem chemistry collective containing continuous controlling created damping density detect detected detection developed dilute direct discovered distant dynamic dynamics enhance enhancement evolution example excitation exploited extreme feedback field fields gain general generating glucose gradients hours immersed improved indirect indirectly inhomogeneity initial input insensitive instability inverted joint largest long longitudinal magnetization manipulating markedly mechanisms modulated moreover near noise nonlinear nuclei overall particularly perturb phantom phys physicians physicists poor precesses prepared problematic process proton pulse radiation recently refocused refocusing represents respectively sample scheme science self sensitivity serve solute solution solvent spatially spectra spectroscopy spin spins standing stem stems subsequent suggests superimposed surmounting target threshold transfer transferred transverse triggering unstable various walls warren weak weakly weakness