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Abstract #0527

Characterization of Structural and Functional Brain Impairment and Phenotypic Association in Autism Spectrum Disorder

Yongxia Zhou1, Xi-Nian Zuo2, Daniel K. Sodickson1, Yulin Ge1, Michael P. Milham3, Robert I. Grossman4, Yvonne W. Lui1

1Radiology/Center for Biomedical Imaging, New York University Langone Medical Center, New York, NY, United States; 2Psychology, Chinese Academy of Sciences, Beijing, China; 3Child Mind Institute, New York University Langone Medical Center, New York, NY, United States; 4Radiology/Center for Biomedical Imaging, New York University, New York, NY, United States

We aim to study the structural and functional connectivity changes of two primary sub-segments of inferior frontal gyrus (IFG) which contain the motor neurons and the subcortical caudate regions in children with autism spectrum disorder (ASD). Data were downloaded from a multi-center Functional Connectome Project including structural and functional MRI data; with a total of 79 children with ASD and 105 age-matched typically developing children. Results showed brain atrophy in IFG, and abnormal caudate and IFG functional connectivity and reduced neuronal activity (via fractional amplitude) in children with ASD. There were significant correlations between fMRI metrics and multiple phenotypic data.

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Keywords

abnormal academy activity ados alterations altered amplitude analyzed association atrophies atrophy authors autism autistic behaviors bilateral biomedical blue brain cerebrum characterization child children china cluster coins communication comparing confirmation connected connections connectivity control controls corrected correlation correlations cortices courses datasets decreased derived developing development diagnostic disorder downloaded entire especially extraction filtering fluid frequency frontal full function functional future gauss gray impaired impairment included increments inferior interview lack lateral library mainly matched materials medial medical mind mirror module motion namely negative network neuronal nuisance orientation package parietal part pattern patterns positive posterior preprocessed preprocessing primary project psychiatry quotient realignment reduced reduction reductions reflecting regional registration regression related released removal resolution resting revised schedule sciences seed seeded seeding seeds segmentation segments selected several significance skull slices smoothing software space spectrum spontaneous statistical steps stripping structural studies superior table task template temporal thank threshold together triangle typically upper visual volumetric warranted white whole years