Meeting Banner
Abstract #0518

Comparison of Diffusion Kurtosis Imaging, Dynamic Susceptibility Weighted Imaging and Short Echo Time Chemical Shift Imaging for Grading Gliomas

Sofie Van Cauter1, Diana M. Sima2, Anca R. Croitor Sava2, Jelle Veraart3, Stefan Sunaert1, 4, Sabine Van Huffel2, Uwe Himmelreich5

1Radiology, University Hospitals of Leuven, Leuven, Vlaams-Brabant, Belgium; 2ESAT-PSI, Department of Electrical Engineering, Catholic University of Leuven, Heverlee, Vlaams-Brabant, Belgium; 3Vision Lab, Department of Physics, University of Antwerp, Antwerp, Belgium; 4Translational MRI, University Hospitals of Leuven, Leuven, Vlaams-Brabant, Belgium; 5Biomedical NMR Unit/Molecular Small Animal Imaging Center, Department of Medical Diagnostic Sciences, KU Leuven, Leuven, Vlaams-Brabant, Belgium

Current routinely used MR techniques are often insufficient in accurate grading of glioma. Hence, in most cases a biopsy is warranted in order to obtain a definitive diagnosis. In this study, we assessed the diagnostic accuracy of diffusion kurtosis imaging, dynamic susceptibility-weighted magnetic resonance imaging and short echo time chemical shift imaging for grading gliomas. The most accurate parameters for determination of glioma grade were mean kurtosis and mean relative regional cerebral blood flow. However, a combination between calculated parameters could still provide a better differentiation between high- and low-grade glioma in this data set.

Abstract PDF Presentation Video

Keywords

acceptance accuracy accurate accurately added adequate advanced although among appealing assess audience belonging best better biomedical biopsy blood capabilities capital catholic cerebral characteristic chemical classification clinical combination combinations combined combining confidence considering course currently curve dataset datasets decision decrease definitive depend detection determination determine determined determining diagnosis diagnostic differentiation difficulties diffusion diffusivity discriminant discriminative distinguish dynamic electrical encountered even examine explored female five flow fractional grade grades grading highest hospitals implementation implementing importance indicated indicates individual interval kurtosis larger linear lips lobe male malignancy many material median medical mentioned modalities molecular moreover needed negative occur operating optimal outside overall panel patient patients performance performances perfusion population positive practical practice predict predictive previously problems prognosis prospective published radiology receiver regimens regional reported rule runs sciences sensitivities sensitivity several short situated specificities specificity statistically step studies sufficient susceptibility table target trans transit translational treatment tree tumor twelve underwent vision warranted year years yield