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Abstract #0507

Evaluate the Efficacy of Intravoxel Incoherent Motion Imaging in Predicting Treatment Outcome in Patients with Head and Neck Cancer

Yonggang Lu1, Jacobus F.A. Jansen2, Hilda E. Stambuk3, Gaorav Gupta4, Nancy Lee4, Mithat Gonen5, Andre E. Moreira6, Snehal G. Patel7, Joseph O. Deasy1, Jatin P. Shah7, Amita Shukla-Dave1, 3

1Medical Physics Department, Memorial Sloan-kettering Cancer Center, New York, NY, United States; 2Department of Radiology, Maastricht University, Maastricht, Netherlands; 3Radiology Department, Memorial Sloan-kettering Cancer Center, New York, NY, United States; 4Radiation Oncology Department, Memorial Sloan-kettering Cancer Center, New York, NY, United States; 5Biostatistics Department, Memorial Sloan-kettering Cancer Center, New York, NY, United States; 6Pathology Department , Memorial Sloan-kettering Cancer Center, New York, NY, United States; 7Surgery Department, Memorial Sloan-kettering Cancer Center, New York, NY, United States

The purpose of this study was to evaluate the efficacy of intravoxel incoherent motion imaging in predicting treatment outcome in patients with head and neck cancer. Sixteen patients with both primary tumor and metastatic nodes were enrolled. The results demonstrated that measures of std(D) in both primary tumors and metastatic nodes were found to be predictors of outcome (progression free (PFS) and overall survival (OS)), but std(D) from primary tumors had more sensitivity in predicting PFS than from metastatic nodes. After appropriate validation in larger patient population, these findings may be useful in optimizing treatment planning and improving patient care.

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