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Abstract #0475

Quantification of Intra-Procedural Gland Motion During Transperineal MRI-Guided Prostate Biopsy

Andriy Fedorov1, Kemal Tuncali1, Tobias Penzkofer1, 2, Junichi Tokuda1, Sang-Eun Song1, Nobuhiko Hata1, Clare Tempany1

1Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States; 2Department of Diagnostic and Interventional Radiology, RWTH Aachen University Hospital , Aachen, North Rhine-Westphalia, Germany

Interventional applications of MRI in PCa management include MRI-guided core needle biopsy that can be recommended for some patient populations, and may lead to improved accuracy of cancer detection. In this work we apply deformable registration retrospectively to recover and quantify intra-procedural motion of the pelvis and prostate gland. Our results show significant motion of the gland, which cannot be fully recovered by compensating for pelvis motion. This can lead to significant errors between the planned and true location of the biopsy target. Application of intra-procedural registration is recommended for intra-procedural quantification and recovery of target motion.

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Keywords

accuracy accurate acquisition alignment although anatomical applications applying approaches array arrow assess audience automatic axial beginning biopsy bone bore bottom bulk cancer centroid centroids challenging characterization checkerboard clinically coil collected combination compensation component confirmation confirmed contoured coordinates course creates deformable deformation detection diagnostic dice dimensional discrepancies discrepancy earlier either enables errors estimation evaluation extent final gland grants green guided hospital identification illustration immobilized improved improvement include included independently indicate inspected inspection intra introduce lead lesion localization location longitudinal magnitude major marked median medical modality motion needle north opposed overlap pair part patient pelvic pelvis placement plan planned planning post potentially precise procedural procedure procedures processed prostate quantification quantified quantify quartile radiologists radiology radius receiver recommended recording recovered recovery registered registration relying resolution retrospectively rigid robotics school segmentation segments separately several since slicer song strategy structures studies sufficient summarized summary superior suspected table target targeting technology transformations true visual visually volume wide