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Abstract #0447

Imaging Glucose Uptake in a Preclinical Brain Tumor Model Using GlucoCEST

Kannie W.Y. Chan1, 2, Guanshu Liu1, 3, Bachchu Lal3, 4, Jeff W.M. Bulte, 25, John Laterra3, 6, Dmitri Artemov7, 8, Michael T. McMahon1, 3, Peter C.M. van Zijl1, 3

1Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States; 2Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering, Baltimore, MD, United States; 3F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States; 4Department of Neurology, Kennedy Krieger Institute, Baltimore, MD, United States; 5Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States; 6Department of Neuroscience, Kennedy Krieger Institute, Baltimore, MD, United States; 7JHU In Vivo Cellular Molecular Imaging Center, The Johns Hopkins University School of Medicine, Baltimore, MD, United States; 8Division of Cancer Imaging Research, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

Neuroimaging has an important role in the diagnosis of tumors, especially to identify different stages of tumor development, the likelihood of metastasis, and the effects of treatment. Recently, Chemical Exchange Saturation Transfer (CEST) MR imaging of natural D-glucose (glucoCEST) was proposed as a novel molecular imaging approach with a biodegradable substrate for tumors. Here we apply this method to visualize glucose uptake in brain tumors, using an orthotopically implanted human brain tumor xenograft in mice. The results show that, using glucoCEST, the tumor glucose uptake can be clearly distinguished from brain glucose uptake.

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Keywords

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