Meeting Banner
Abstract #0445

Synthesis and Evaluation of CREKA-Tris(Gd-DOTA)3 for MR Molecular Imaging of Breast Cancer

Zhuxian Zhou1, Zhen Ye1, Xueming Wu1, Zheng-Rong Lu1

1Biomedical Engineering, Case Western Reserve Universtiy, Cleveland, OH, United States

MRI is a powerful medical imaging modality to display anatomical structures of body, especially useful for the detection and characterization of diseased soft tissues such as solid tumors. Various targeted contrast agents have been prepared for cancer molecular imaging with MRI. However, MRI is not effective for molecular imaging because of its low sensitivity. Most of these agents could not generate sufficient contrast enhancement because of low concentration of biomarkers on cancer cell surface. CREKA is a tumor-homing pentapeptide (Cys-Arg-Glu-Lys-Ala) specifically homes to tumors by binding to fibrin and fibronectin associated plasma protein clots in tumor stroma. Thus, we synthesized and evaluated a new tumor-targeted contrast agent CREKA-Tris(Gd-DOTA)3 for MR molecular imaging of breast cancer

Abstract PDF Presentation Video

Keywords

able agent agents amount anatomical anesthetized anti antibody arrows axial bearing binding biomedical body breast cancer cell cells chamber characterization chemistry click clots coil collected concentration confocal conjugated conjugating contrast corp deliver detected detection diseased display dose effective engineering enhancement especially evaluated evaluation fibrin fluorescence functional generate goat healthy homes homing identified implant indicate induction injected injection intravenously laboratories little medical mice microscope minutes mixture modality molecular mouse much nuclei overlay oxygen peptide plasma post powerful prepared protein rabbit representative reserve respectively sacrificed scaffold scanner sectioned sections sensitivity slice slices soft solid specifically stained staining stronger structure structures studied sufficient suitable suppression surface synthesis synthesized target targeted targets tissue tissues tumor tumors useful various volume weeks western white