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Abstract #0406

Water-Fat MR Imaging for Assessing Changes in Bone Marrow Composition Due to Radiation and Chemotherapy in Gynecologic Cancer Patients

Patrick J. Bolan1, Luke Arentsen2, Thanasak Sueblinvong3, Yan Zhang4, Steen Moeller1, Jori Carter3, Levi S. Downs3, Rahel Ghebre3, Douglas Yee4, 5, Jerry Froelich1, Susanta K. Hui4, 6

1Radiology, University of Minnesota, Minneapolis, MN, United States; 2Medical Physics, University of Minnesota, Minneapolis, MN, United States; 3Obstetrics and Gynecology, University of Minnesota, Minneapolis, MN, United States; 4Masonic Cancer Center, University of Minnesota, Minneapolis, MN, United States; 5Department of Medicine, University of Minnesota, Minneapolis, MN, United States; 6Therapeutic Radiology, University of Minnesota, Minneapolis, MN, United States

This work demonstrates the feasibility of rapidly acquiring high-resolution 3D signal fat fraction (sFF) maps from mid-femur to the L3 lumbar vertebra, and that the sFF can detect and characterize marrow composition changes induced by chemotherapy and radiation therapy. The marrow fat fraction is potentially an imaging biomarker of bone marrow health and may be useful in planning and monitoring treatment of cancer patients.

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Keywords

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