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Abstract #0387

GABA Level Correlates with Occupational Manganese Exposure and Motor Tests in Smelters

Zaiyang Long1, 2, Yue-Ming Jiang3, Xiang-Rong Li4, Jun Xu1, 2, Li-Ling Long4, Wei Zheng1, James B. Murdoch5, Ulrike Dydak1, 2

1School of Health Sciences, Purdue University, West Lafayette, IN, United States; 2Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States; 3Dept. of Occupational Health and Toxicology, Guangxi Medical University, Nanning, Guangxi, China; 4Department of Radiology, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China; 5Toshiba Medical Research Institute USA, Mayfair village, OH, United States

Manganese (Mn) overexposure can lead to parkinson-type motor symptoms, for which no treatment exists to date. Nine Mn-exposed smelters and ten controls were recruited and underwent Purdue pegboard test to access manual dexterity and steadiness. A GABA-edited proton spectrum was acquired from the thalamus using the MEGA-PRESS sequence on a 3T Philips Achieva whole-body clinical scanner. We found a significant correlation between the increase in GABA+/total creatine (tCr) and the duration of exposure, and significant inverse correlations between GABA+/tCr and all Purdue pegboard test scores. GABA+ may function as a biomarker of Mn-induced toxic effects, in particular of motor deficits.

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Keywords

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