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Abstract #0322

Subcellular Distribution of Manganese and Its Impact on Mitochondrial Function in Rat Cardiac Myocytes

Ya Chen1, Mariana G. Rosca2, Charles L. Hoppel2, 3, Xin Yu1

1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States; 2School of Medicine, Case Western Reserve University, Cleveland, OH, United States; 3Department of Pharmacology, Case Western Reserve University, Cleveland, OH, United States

This study aims to elucidate the mechanisms leading to long Mn2+ retention in cardiac myocytes. Subcellular distribution of Mn2+ was delineated by ICP-OES. The impact of Mn2+ accumulation on mitochondrial respiration was also assessed by isolated mitochondrial studies.

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Keywords

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